Since the first case of COVID-19 in Latin America and the Caribbean was reported in Brazil on February 26, 2020, the region has reported nearly 22.2 million cases and more than 700,000 COVID-related deaths. Countries have actively worked to secure vaccines through bilateral and multilateral arrangements, including agreements with Pfizer, Moderna, AstraZeneca, Russia’s Sputnik V, and China’s CoronaVac.