The number of people dying from coronavirus in Italy has risen by 475 in one day to nearly 3,000 - the biggest increase since the outbreak.
There are a total of 35,713 confirmed cases in the country, with more than 4,000 having successfully recovered.
Lombardy, the worst-hit region, recorded 319 deaths in one day.
Italy is the world's worst affected country after China, where the virus originated last year. At least 8,758 people have died, most in China.
Spain now has 598 dead and 13,716 infections. An inquiry is to be launched into the deaths of at least 17 residents of a nursing home in Madrid, where dozens of cases of Covid-19 have been reported.
In France, the number of confirmed cases grew by more than 16% on Tuesday, reaching 7,730, while the death toll rose to 175, with 7% of the dead aged under 65.
In the UK, the number of dead has reached 104.
Germany has 12 deaths and 8,198 cases. In a TV address, Chancellor Angela Merkel urged Germans to abide by restrictions aimed at combating the pandemic. "Since German reunification, actually, since World War Two, there has never been a challenge for our country in which acting in solidarity was so very crucial," she said.