Beautiful Virgin Islands

Saturday, Feb 22, 2025

How did coronavirus start and where did it come from? Was it really Wuhan's animal market?

How did coronavirus start and where did it come from? Was it really Wuhan's animal market?

It’s likely Covid-19 originated in bats, scientists say. But did it then spread to pangolins and humans?
In the public mind, the origin story of coronavirus seems well fixed: in late 2019 someone at the now world-famous Huanan seafood market in Wuhan was infected with a virus from an animal.

The rest is part of an awful history still in the making, with Covid-19 spreading from that first cluster in the capital of China’s Hubei province to a pandemic that has killed about 80,000 people so far.

Stock footage of pangolins – a scaly mammal that looks like an anteater – have made it on to news bulletins, suggesting this animal was the staging post for the virus before it spread to humans.

But there is uncertainty about several aspects of the Covid-19 origin story that scientists are trying hard to unravel, including which species passed it to a human. They’re trying hard because knowing how a pandemic starts is a key to stopping the next one.

Prof Stephen Turner, head of the department of microbiology at Melbourne’s Monash University, says what’s most likely is that virus originated in bats.

But that’s where his certainty ends, he says.

On the hypothesis that the virus emerged at the Wuhan live animal market from an interaction between an animal and a human, Turner says: “I don’t think it’s conclusive by any means.”

“Part of the problem is that the information is only as good as the surveillance,” he says, adding that viruses of this type are circulating all the time in the animal kingdom.

The fact that the virus has infected a tiger in a New York zoo shows how viruses can move around between species, he says. “Understanding the breadth of species this virus can infect is important as it helps us narrow down down where it might have come from.”

Scientists say it is highly likely that the virus came from bats but first passed through an intermediary animal in the same way that another coronavirus – the 2002 Sars outbreak – moved from horseshoe bats to cat-like civets before infecting humans.

One animal implicated as an intermediary host between bats and humans is the pangolin. The International Union for Conservation of Nature says they are “the most illegally traded mammal in the world” and are prized for their meat and the claimed medicinal properties of their scales.

As reported in Nature, pangolins were not listed on the inventory of items being sold in Wuhan, although this omission could be deliberate as it’s illegal to sell them.

“Whether the poor pangolin was the species at which it jumped, it’s not clear,” Turner says. “It’s either mixed in something else, mixed in a poor pangolin, or it’s jumped into people and evolved in people.”

Prof Edward Holmes, of the University of Sydney, was a co-author on a Nature study that examined the likely origins of the virus by looking at its genome. On social media he has stressed that the identity of the species that served as an intermediate host for the virus is “still uncertain”.

One statistical study looked at a characteristic of the virus that evolved to enable it to latch on to human cells. Pangolins were able to develop this characteristic, but so were cats, buffalo, cattle, goats, sheep and pigeons.

Another study claimed to have ruled out pangolins as an intermediary altogether, because samples of similar viruses taken from pangolins lacked a chain of amino acids seen in the virus now circulating in humans.

The study Holmes worked on suggested that the scenario in which a human at the Wuhan market interacted with an animal that carried the virus was only one potential version of the Covid-19 origin story. Another was the possibility that a descendent of the virus jumped into humans and then adapted as it was passed from human to human.

“Once acquired, these adaptations would enable the pandemic to take off and produce a sufficiently large cluster of cases to trigger the surveillance system that detected it,” the study said.

Analysis of the first 41 Covid-19 patients in medical journal the Lancet found that 27 of them had direct exposure to the Wuhan market. But the same analysis found that the first known case of the illness did not.

This might be another reason to doubt the established story.

Prof Stanley Perlman, a leading immunologist at the University of Iowa and an expert on previous coronavirus outbreaks that have stemmed from animals, says the idea the link to the Wuhan market is coincidental “cannot be ruled out” but that possibility “seems less likely” because the genetic material of the virus had been found in the market environment.

Perlman told Guardian Australia he does believe there was an intermediary animal but adds that while pangolins are possible candidates, they “are not proven to be the key intermediary”.

“I suspect that any evolution [of the virus] occurred in the intermediate animal if there was one. There has been no substantial changes in the virus in the three months of the pandemic, indicating that the virus is well adapted to humans.”

So-called wet markets – where live animals are traded – have been implicated in previous outbreaks of coronaviruses, in particular Sars.

Dr Michelle Baker, an immunologist at CSIRO who studies viruses in bats, says some of the research on Covid-19’s origins have stepped off from what was known from the past.

But “we really don’t know” how accurate the origin story is, she says: “There’s some sort of connection [to the Wuhan market] and there were people exposed to the market that were infected.”

Baker says what is “very likely” is that the virus originated in a bat. “It’s a likely scenario but we will never know. The market was cleaned up quite quickly. We can only speculate.”

“These wet markets have been identified as an issue because you do have species interacting,” she says. “It’s an opportunity to highlight the dangers of them and an opportunity to clamp down on them.”

Turner adds: “We’ve found the ancestors of the virus, but having broader knowledge of the coronavirus in other species might give us a hint about the evolution of this thing and how it jumped.”
Newsletter

Related Articles

Beautiful Virgin Islands
0:00
0:00
Close
Good News: Senate Confirms Kash Patel as FBI Director
Officials from the U.S. and Hungary Engage in Talks on Economic Collaboration and Sanctions Strategy
James Bond Franchise Transitions to Amazon MGM Studios
Technology Giants Ramp Up Lobbying Initiatives Against Strict EU Regulations
Alibaba Exceeds Quarterly Projections Fueled by Growth in Cloud and AI
Tequila Sector Faces Surplus Crisis as Agave Prices Dive Sharply
Residents of Flintshire Mobile Home Park Grapple with Maintenance Issues and Uncertain Future
Ronan Keating Criticizes Irish Justice System Following Fatal Crash Involving His Brother
Gordon Ramsay's Lucky Cat Restaurant Faces Unprecedented Theft
Israeli Family Mourns Loss of Peace Advocate Oded Lifschitz as Body Returned from Gaza
Former UK Defense Chief Calls for Enhanced European Support for Ukraine
Pope Francis Admitted to Hospital in Rome Amid Rising Succession Speculation
Senate Republican Leader Mitch McConnell, at the age of 83, Declares His Retirement.
Whistleblower Reveals Whitehall’s Focus on Kabul Animal Airlift Amid Crisis
Politicians Who Deliberately Lie Could Face Removal from Office in Wales
Scottish Labour Faces Challenges Ahead of 2026 Holyrood Elections
Leftwing Activists Less Likely to Work with Political Rivals, Study Finds
Boris Johnson to Host 'An Evening with Boris Johnson' at Edinburgh's Usher Hall
Planned Change in British Citizenship Rules Faces First Legal Challenge
Northumberland Postal Worker Sentenced for Sexual Assaults During Deliveries
British Journalist Missing in Brazil for 11 Days
Tesco Fixes Website Glitch That Disrupted Online Grocery Orders
Amnesty International Critiques UK's Predictive Policing Practices
Burglar Jailed After Falling into Home-Made Trap in Blyth
Sellafield Nuclear Site Exits Special Measures for Physical Security Amid Ongoing Cybersecurity Concerns
Avian Influenza Impact on Seals in Norfolk: Four Deaths Confirmed
First Arrest Under Scotland's Abortion Clinic Buffer Zone Law Amidst International Controversy
Meghan Markle Rebrands Lifestyle Venture as 'As Ever' Ahead of Netflix Series Launch
Inter-Island Ferry Services Between Guernsey and Jersey Set to Expand
Significant Proportion of Cancer Patients in England and Wales Not Receiving Recommended Treatments
Final Consultation Launched for Vyrnwy Frankton Power Line Project
Drug Misuse Deaths in Scotland Rise by 12% in 2023
Failed £100 Million Cocaine Smuggling Operation in the Scottish Highlands
Central Cee Equals MOBO Awards Record; Bashy and Ayra Starr Among Top Honorees
EastEnders: Four Decades of Challenging Social Norms
Jonathan Bailey Channels 'Succession' in Bold Richard II Performance
Northern Ireland's First Astronaut Engages in Rigorous Spacewalk Training
Former Postman Sentenced for Series of Sexual Offences in Northumberland
Record Surge in Anti-Muslim Hate Crimes Across the UK in 2024
Omagh Bombing Inquiry Concludes Commemorative Hearings with Survivor Testimonies
UK Government Introduces 'Ronan's Law' to Combat Online Knife Sales to Minors
Metal Detectorists Unearth 15th-Century Coin Hoard in Scottish Borders
Woman Charged in 1978 Death of Five-Year-Old Girl in South London
Expanding Sinkhole in Godstone, Surrey, Forces Evacuations and Road Closures
Bangor University Announces Plans to Cut 200 Jobs Amid £15 Million Savings Target
British Journalist Charlotte Peet Reported Missing in Brazil
UK Inflation Rises to 3% in January Amid Higher Food Prices and School Fees
Starmer Defends Zelensky Amidst Trump's 'Dictator' Allegation
Zelensky Calls on World Leaders to Back Peace Efforts in Light of Strains with Trump
UK Prime minister, Mr. Keir Starmer, has stated that any peace agreement aimed at ending the conflict in Ukraine "MUST" include a US security guarantee to deter Russian aggression
×