Beautiful Virgin Islands

Friday, Feb 03, 2023

Scientists take ‘important step’ in stem cell therapy to treat Parkinson’s

Scientists take ‘important step’ in stem cell therapy to treat Parkinson’s

Chinese Academy of Sciences team discovered a new technique they say improved efficacy and safety in study on mice.

Chinese researchers have discovered a new technique they say improved the efficacy and safety of stem cell therapy in mice models of Parkinson’s disease.

The team from the Chinese Academy of Sciences (CAS) said their study findings paved the way for potentially developing a stem cell therapy to treat the disease.

The researchers identified two cell surface markers of dopamine neurons, which are damaged or destroyed in the midbrain of someone with Parkinson’s disease.

They then injected cells with these markers into the brains of mice, which they found could significantly improve the dopamine neurons in the midbrain – a key step in the treatment of the disease.

The finding “represents a revolutionary step on the road towards more effective and safer stem cell therapies”, according to the study, published in the Journal of Clinical Investigation on Tuesday.

Neurological disorders are the leading source of disability globally, and Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s. There is no cure for Parkinson’s disease, but the symptoms can be managed with medications and other therapies.

Worldwide, some 6.1 million people had Parkinson’s disease in 2016, according to the Lancet’s Global Burden of Disease Study in 2018. That number is expected to double to more than 12 million by 2040.

In China, it is estimated that the number of Parkinson’s disease patients could rise to about 5 million by 2030, accounting for half of the world’s cases.

Parkinson’s disease is a degenerative disorder affected by the impairment or death of cells in deep parts of the brain called the substantia nigra, which produces the neurotransmitter dopamine and controls body movement.

When 60 to 80 per cent of dopamine is lost, Parkinson’s symptoms such as tremor and balance problems occur.

Stem cell therapy is considered to be a promising treatment strategy because the disease is caused by the loss of one type of cell from a certain spot in the brain.

“Parkinson’s disease is the most suitable one [for stem cell therapy] because it is very clear which cells are lost and where should they be transplanted,” said Chen Yuejun, corresponding author of the study and a researcher with the CAS.

However, previous studies have generated both target and off-target neuronal cells during transplantation, resulting in low efficacy and uncertainty around safety.

“Our study wanted to answer two questions – why the previous studies generated more than a dozen off-target cells, and how we could enrich [certain] cells,” said Chen, who heads the Laboratory of Neural Differentiation and Regeneration at the CAS.

Stem cell therapy is seen as a promising strategy to treat Parkinson’s disease.

Chen and the team did a single-cell sequencing of dopaminergic neurons and found that the off-target cells were generated in areas near the midbrain.

They also found two markers that could facilitate highly enriched dopaminergic neurons after transplantation.

The percentage of neurons could be as high as 80 per cent in the transplant area, according to the paper. That compares to about 10 per cent in two recent preclinical studies.

“The study established a method for obtaining highly purified donor cells that can be transplanted with stable and predictable cell therapy results,” the authors said in a statement on the CAS website.

“It is an important step towards more effective and safer cell therapy for Parkinson’s disease.”


Related Articles

Beautiful Virgin Islands
EU found a way to use frozen Russian funds
I have a dream, MLK inspiring speech
First generation unopened iPhone set to fetch more than $50,000 at auction.
Aretha Franklin, Marvis Staples - Oh Happy Day
WARNING GRAPHIC CONTENT - US Memphis Police murdering innocent Tyre Nichols
BVI Freedom Song
Almost 30% of professionals say they've tried ChatGPT at work
Billy Preston - You Can't Beat God Giving (Live)
Interpol seeks woman who ran elaborate exam cheating scam in Singapore
What is ChatGPT?
Oh Happy Day Edwin Hawkins - Anthony Brown w FBCG Combined Choir
Bill Gates is ‘very optimistic’ about the future: ‘Better to be born 20 years from now...than any time in the past’
'Stand by Me' performed by Karen Gibson and The Kingdom Choir
Tesla reported record profits and record revenues for 2022
National Anthem of the British Virgin Islands - Oh, Beautiful Virgin
Prince Andrew and Virginia Giuffre Photo Is Fake: Ghislaine Maxwell
Hello Dolly
Opinion | Israel’s Supreme Court Claims a Veto on Democracy
for KING & COUNTRY - Amen (Reborn) [feat. Lecrae & The WRLDFMS Tony Wi
Moonwalker Buzz Aldrin Gets Married On His 93rd Birthday
Bob Marley - Get Up Stand Up
Who’s Threatening Israeli Democracy?
Yes He Can
Federal Reserve Probes Goldman’s Consumer Business
What A Friend We Have In Jesus
China's first population drop in six decades
Microsoft is finalising plans to become the latest technology giant to reduce its workforce during a global economic slowdown
Touch The Hem Of His Garment
China's foreign ministry branch in Hong Kong urges British gov't to stop the biased and double standards Hong Kong report
The Lord's Prayer
Tesla slashes prices globally by as much as 20 percent
1.4 Million Copies Of Prince Harry's Memoir 'Spare' Sold On 1st Day In UK
After Failing To Pay Office Rent, Twitter May Sell User Names
Ray Charles And The Voices Of Jubilaton, Oh, Happy Day
Lisa Marie Presley, singer and daughter of Elvis, dies aged 54
Ramblin' Rose
FIFA president questioned by prosecutors
Protoje - Who Knows ft. Chronixx
Britain's Sunak breaks silence and admits using private healthcare
Pressure - Virgin Islands Nice
Hype and backlash as Harry's memoir goes on sale. Unnamed royal source says prince 'kidnapped by cult of psychotherapy and Meghan'
Phil Wickham - House Of The Lord
Saudi Arabia set to overtake India as fastest-growing major economy this year 
My God Is Real (Yes, God Is Real)
Google and Facebook’s dominance in digital ads challenged by rapid ascent of Amazon and TikTok
The Lion King Circle of Life by LEBO M. — LIVE at the HAVASI Symphonic
FTX fraud investigators are digging deeper into Sam Bankman-Fried's inner circle – and reportedly have ex-engineer Nishad Singh in their sights
Louis Armstrong - When The Saints Go Marching In
TikTok CEO Plans to Meet European Union Regulators
Kanye West Sunday Service - hallelujah, salvation, and glory
UK chaos: Hong Kong emigrants duped by false prospectus
Jonathan Nelson - I Believe (Island Medley
France has banned the online sale of paracetamol until February, citing ongoing supply issues
From The Virgin Islands Sqad Up
Japan reportedly to give families 1 million yen per child to move out of Tokyo
Common, John Legend - Glory
Will Canada ever become a real democracy?
Anthony Evans vs. Jesse Campbell - If I Ain't Got You
Hong Kong property brokerages slash payrolls in choppy market
I have a dream, MLK inspiring speech
U.S. Moves to Seize Robinhood Shares, Silvergate Accounts Tied to FTX
Aretha Franklin, Marvis Staples - Oh Happy Day
Effect of EU sanctions on Moscow is ‘less than zero’ – Belgian MEP
BVI Freedom Song
Coinbase to Pay $100 Million in Settlement With New York Regulator
Billy Preston - You Can't Beat God Giving (Live)